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Arimidex (Anastrozole)

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Updated on: 2015-03-17 11:46
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 Product Name: Arimidex (Anastrozole)

CAS: 120511-73-1

Purity: 99%

M.F.: C17H19N5

M.W: 293.37

Appearance: White crystalline powder

Identification: IR, HPLC, Reactive: positive

Solubility: Freely soluble in methanol, acetone, ethanol and tetrahydrofuran. Easily soluble in acetonitrile.

Related Substance: Total Impurities: 0.5% max.

                Total Unspecified Impurity: 0.2% max.

                Any individual unknown impurity: 0.1% max.

                Related compound B: 0.2% max.

                Related compound C: 0.2% max.

                Related compound D: 0.1% max.

                Related compound E: 0.1% max.

Limit of Cyclohexane: 0.08% max.

Limit of Ethylacetate: 0.1% max.

Melting point: 81.0°C ~ 84.0°C

Loss on Drying: 0.3% max.

Residue on Ignition: 0.1% max.

Heavy metals: 0.001% max.

Assay (by HPLC): 98.0% ~ 102.0%

Standard: USP36

Details: Arimidex (anastrozole) is the aromatase inhibitor of choice. Arimidex’s mechanism of action - blocking conversion of aromatizable steroids to estrogen - is in contrast to the mechanism of action of anti-estrogens such as clomiphene (Clomid) or tamoxifen (Nolvadex), which block estrogen receptors in some tissues, and activate estrogen receptors in others.
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